#Kidney

Kidney's Role in Blood Sugar Homeostasis

Most of us may not know that the kidneys also play a role in regulating blood sugar levels in our body. This unawareness can be caused by, among others, the lack of information on this matter or the limited time to find out, because it is generally assumed that the function of the kidneys is only to remove toxins or water no longer needed by the body. In fact, kidney's functions are more diverse. The functions include filtration, absorption, secretion, and excretion. In clinical practice, kidney functions are described as regulating blood pressure, removing toxins and electrolyte waste, regulating the body's acid-base levels, producing hormones (such as erythropoietin, vitamin D), and regulating water and sodium balance. In addition, the kidneys also play a major role in regulating blood sugar levels through a certain mechanism. Therefore, it is natural that these various functions are less known.

Severe Covid-19 infection in a kidney transplant recipient treated with lopinavir/ritonavir, hydroxychloroquine and dexamethasone

Abstract Severe COVID-19 infection management for a recipient of kidney transplant has debatable prognosis and treatment. We described the case of a COVID-19 infected 70 year old female, previously had renal transplantation in 2017. The patient took immunosuppressive agents as routine drugs for transplant recipient status and received lopinavir/ritonavir, hydroxychloroquine, and dexamethasone daily at the hospitalization. Specific question arises about renal transplant recipients being infected by COVID-19 - whether the infection will get worse compared to those without immunosuppresive agent. In this case, author decided to stop the immunosuppressive agent followed administration of combination lopinavir/ritonavir, hydroxychloroquine, and dexamethasone that gives a good clinical impact change to patient's condition after once getting worsened and mechanically ventilated.

Effect of Ethanolic Extract of Cayratia trifolia on Histologically Kidney Mouse Model

Abstract - This study was conducted to determine the effect of Cayratia trifolia ethanolic extract on histological mouse kidney models. A total of 12 adult male Balb/c mice were randomly divided into two groups, comprising six mice in each group. The first group of 6 mice provided as the control group and received 25 ml/kg BW orally sodium carboxymethylcellulose during 6 days.The second group, 6 mice was administered 50 mg/kg BW of C. trifolia ethanolic extract in sodium carboxymethylcellulose orally during 6 days. The present study, we have performed histological kidney mice evaluation after 6 days of C. trifolia ethanolic extract administration. The histological mice kidney was quantified in term of tubular epithelium, glomerular and focal mononuclear infiltrate. The effect of administration of C. trifolia ethanolic extract on histological kidney of mice appeared normal tubular morphology in cortical and medullary regions of kidney in administered C. trifolia ethanolic extract mice, there was no kidney change histologically showed normal architecture of the glomerulus and tubules, while in control mice group, kidney histologically first marked with mononuclear cell infiltration, tubular necrosis, glomerular congestion and hyaline casts.

Preparation and characterization of imprinted zeolite-Y for p-cresol removal in haemodialysis

Rumah Ginjal - In this work, the novel imprinted zeolite (IZ) was synthesized, and its properties and performance in terms of adsorption of p-Cresol, which represent the protein-bounded uremic toxins in aqueous phase under phosphate buffer saline, were studied and compared with the synthesized zeolite-Y (ZeoY-S) and commercial CBV 100 zeolite-Y (ZeoY-C).The ZeoY-S was synthesized from sodium aluminate, NaOH, H2O and SiO2 under aging for 24 h at room temperature and hydrothermal condition for 24 h at 100 °C, with an initial composition of 10SiO2:Al2O3:4Na2O:180H2O.